Ethanol → HCID 69944757, compound

HRID 376394Notes

Reaction equation

HRID 376394 reaction equation
Cl.[NH2:2][N:3]=[CH:4][C:5]1[CH:29]=[CH:28][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]3[O:20][CH:19]([CH2:21][C:22]([O:24]CC)=[O:23])[CH2:18][CH2:17][C:16]=3[CH:27]=2)=[O:10])=[C:7]([Cl:30])[CH:6]=1.C(O)C.[OH-].[Na+]>C(O)(=O)C>[NH2:2][N:3]=[CH:4][C:5]1[CH:29]=[CH:28][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]3[O:20][CH:19]([CH2:21][C:22]([OH:24])=[O:23])[CH2:18][CH2:17][C:16]=3[CH:27]=2)=[O:10])=[C:7]([Cl:30])[CH:6]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 69945177HCID 69945177, compound

Product 1

HCID 69944757HCID 69944757, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

0.3 g (0.66 mmol) of the ester from Example 75 were stirred overnight at room temperature with a mixture of 5 ml ethanol and 0.5 ml 2 N aqueous sodium hydroxide solution. It was brought to pH 5 with 2 N acetic acid. The precipitate of the title compound was filtered with suction, washed successively with water and with acetone, and dried in vacuo. Yield: 0.19 g (74%) of a white powder, m.p. 269-270° C.(dec.).

Workup

  1. filtrationThe precipitate of the title compound was filtered with suction
  2. washwashed successively with water and with acetone
  3. customdried in vacuo

Sources & evidence

ORD record
ord-f264d4326af84e5f8890e14e099bd60c
Source dataset
uspto-grants-2000_02
Patent number
US06020362

Reaction notes

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