Sodium Hydroxide → HCID 69946613, compound

Participants

Reaction Steps

0.3 g (0.67 mmol) of the ester from Example 79 were suspended in 10 ml ethanol followed by addition of 1 ml aqueous 2 N sodium hydroxide. It was stirred at room temperature for 4 hours. The mixture was filtered, the filtrate concentrated to dryness under reduced pressure, and the residue was dissolved in water. It was then neutralized with diluted acetic acid, and the precipitate of the compound (336) was filtered with suction, washed thoroughly with water, and dried in vacuo at 50° C. Yield: 0.2 g (78%) of a yellow crystalline solid, m.p. 248-250° C.

Provenance & Evidence