Ethanol → HCID 69946752, compound

HRID 376397Notes

Reaction equation

HRID 376397 reaction equation
Cl.[CH2:2]([NH:5][N:6]=[CH:7][C:8]1[CH:32]=[CH:31][C:11]([C:12]([NH:14][C:15]2[CH:16]=[CH:17][C:18]3[O:23][CH:22]([CH2:24][C:25]([O:27]CC)=[O:26])[CH2:21][CH2:20][C:19]=3[CH:30]=2)=[O:13])=[CH:10][CH:9]=1)[CH2:3][CH3:4].C(O)C.[OH-].[Na+]>C(O)(=O)C>[CH2:2]([NH:5][N:6]=[CH:7][C:8]1[CH:32]=[CH:31][C:11]([C:12]([NH:14][C:15]2[CH:16]=[CH:17][C:18]3[O:23][CH:22]([CH2:24][C:25]([OH:27])=[O:26])[CH2:21][CH2:20][C:19]=3[CH:30]=2)=[O:13])=[CH:10][CH:9]=1)[CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 69945036HCID 69945036, compound

Product 1

HCID 69946752HCID 69946752, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

0.25 g (0.54 mmol) of the ester from Example 81 were stirred at room temperature overnight with 5 ml ethanol and 0.7 ml 2 N aqueous sodium hydroxide. The mixture was brought to pH 4 with 2 N acetic acid, and the precipitate of the acid (338) was filtered with suction, washed successively with water and with acetone, and dried in vacuo. Yield: 0.16 g (74%) of a pale yellow powder, m.p. 241-242° C. (dec.).

Workup

  1. filtrationthe precipitate of the acid (338) was filtered with suction
  2. washwashed successively with water and with acetone
  3. customdried in vacuo

Sources & evidence

ORD record
ord-999793d1434b444fbfb16bb1b5a20b25
Source dataset
uspto-grants-2000_02
Patent number
US06020362

Reaction notes

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