Propyl chloroformate → HCID 54259956, compound

HRID 376401Notes

Reaction equation

Cl.[NH2:2][N:3]=[CH:4][C:5]1[CH:29]=[CH:28][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]3[O:20][CH:19]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:18][CH2:17][C:16]=3[CH:27]=2)=[O:10])=[C:7]([F:30])[CH:6]=1.Cl[C:32]([O:34][CH2:35][CH2:36][CH3:37])=[O:33]>>[F:30][C:7]1[CH:6]=[C:5]([CH:4]=[N:3][NH:2][C:32]([O:34][CH2:35][CH2:36][CH3:37])=[O:33])[CH:29]=[CH:28][C:8]=1[C:9]([NH:11][C:12]1[CH:13]=[CH:14][C:15]2[O:20][CH:19]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:18][CH2:17][C:16]=2[CH:27]=1)=[O:10]

Participants

Reactant 2

HCID 7998Propyl chloroformate

HCID 69945842HCID 69945842, compound

Product 1

HCID 54259956HCID 54259956, compound

Procedure

The title compound was prepared as described in Example 85 from 436 mg (1.0 mmol) of the amidine from Example 69 and 135 mg (1.1 mmol) propyl chloroformate. Yield: 0.29 g (60%) of a white crystalline solid, m.p. 157-159° C.

Sources & evidence

ORD record: ord-544828409c744b1dbadbb321aba7bb81
Source dataset: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06020362

Reaction notes

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