Acetic Acid → HCID 67618501, compound

HRID 376402Notes

Reaction equation

HRID 376402 reaction equation
Cl.[CH2:2]([NH:7][N:8]=[CH:9][C:10]1[CH:34]=[CH:33][C:13]([C:14]([NH:16][C:17]2[CH:18]=[CH:19][C:20]3[O:25][CH:24]([CH2:26][C:27]([O:29]CC)=[O:28])[CH2:23][CH2:22][C:21]=3[CH:32]=2)=[O:15])=[CH:12][CH:11]=1)[CH2:3][CH2:4][CH2:5][CH3:6].C(O)(=O)C>C(O)C.[OH-].[Na+]>[CH2:2]([NH:7][N:8]=[CH:9][C:10]1[CH:34]=[CH:33][C:13]([C:14]([NH:16][C:17]2[CH:18]=[CH:19][C:20]3[O:25][CH:24]([CH2:26][C:27]([OH:29])=[O:28])[CH2:23][CH2:22][C:21]=3[CH:32]=2)=[O:15])=[CH:12][CH:11]=1)[CH2:3][CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 69944777HCID 69944777, compound

Product 1

HCID 67618501HCID 67618501, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

0.15 g (0.31 mmol) of the ester from Example 94 were stirred overnight at room temperature in a mixture of 10 ml ethanol and 0.7 ml 2 N aqueous sodium hydroxide solution. It was brought to pH 4 with 2 N acetic acid, and the precipitate of the title acid was filtered, washed successively with water and with acetone, and dried in vacuo. Yield: 98 mg (75%) of colorless crystals, m.p. 223-225° C. (dec.).

Workup

  1. filtrationthe precipitate of the title acid was filtered
  2. washwashed successively with water and with acetone
  3. customdried in vacuo

Sources & evidence

ORD record
ord-325204b4a20140a7befba47e3989ddfb
Source dataset
uspto-grants-2000_02
Patent number
US06020362

Reaction notes

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