Sulfuric Acid → 2-Nitrotoluene

Participants

Reaction Steps

The toluene derivative (h) is charged with concentrated sulfuric acid and potassium nitrate to obtain the 2-nitrotoluene derivative (i) (reaction 7), which is subsequently reduced (reaction 8) with hydrogen over Raney-nickel to the amine (j). In a Sandmeyer reaction (reaction 9) with amylnitrate and the halogenide (R7 -Hal) in the presence of copper, the toluene derivative (k) is obtained. The reaction with chromium(VI)oxide in acetic acid leads to the aldehyde (a).

Provenance & Evidence