反应详情

2-Acetylfluorene (4.17 g, 20 mmol) and cycloheptylamine (2.38 g, 21 mmol) were heated together at 130° C. for 14 hrs and, then, distilled under reduced pressure. To the residue were added ethanol (20 ml) and sodium borohydride (0.76 g, 20 mmol) and the mixture was stirred at room temperature overnight. The mixture was then diluted with water (100 ml) and extracted with chloroform (80 ml×2 times). The organic layer was dried over anhydrous magnesium sulfate and concentrated. The residue was then purified by silica gel column chromatography to give 1.58 g of the amine compound.

1. distillationdistilled under reduced pressure
2. extractionextracted with chloroform (80 ml×2 times)
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. concentrationconcentrated
5. customThe residue was then purified by silica gel column chromatography