Methanethiol → 5'-Fluoro-2'-Formyl-4-Methylthiobiphenyl

Participants

Reaction Steps

85% potassium hydroxide solution (66 g) is dissolved in ethanol (700 ml) and cooled to room temperature. To this with stirring is added methyl mercaptan subsurface (50 g), water (2ml) and a solution of 4-chloro-5'-fluoro-2'-formylbiphenyl (234.5 g) in ethanol (300 ml). A slow stream of methyl mercaptan is continuously fed in while the reaction mixture is held at reflux for 3 hours. The reaction is poured into water (1 liter), and the solid is filtered off. The solid is recrystallized from benzene.

Provenance & Evidence