Benzaldehyde → (R)-(+)-1-Phenyl-1-propanol

Participants

Reaction Steps

Reaction of benzaldehyde with diethylzinc in the presence of the polymer of Example 6 to give (R)-1-phenyl-1-propanol. The polymer of Example 6 (Mw=24,300 and Mn=9900, PDI=2.45) was used to catalyze the addition reaction of diethylzinc to an aldehyde according to the procedure of Example 4. For benzaldehyde, the yield was 90% with ee of 92.7% ((R) product). For p-chloro-benzaldehyde, the yield was 95% with ee of 93.8% ((R) product).

Provenance & Evidence