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HRID376486

反应详情

EQUATION

反应方程式

HRID 376486 的结构方程式

REACTANTS

反应物

3
结构：[Gd]
HCID23982

Gadolinium

Gd

结构：O=C([O-])CN1CCNCCN(CC(=O)[O-])CCN(CC(=O)[O-])CC1.[Na+].[Na+].[Na+]
HCID10862527

未命名化合物

结构：CC1(C)OCC2OC2CO1
HCID11094747

4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane

C7H12O3

PRODUCTS

生成物

1
结构：O=C([O-])CN1CCN(CC(=O)[O-])CCN(C(CO)C(O)CO)CCN(CC(=O)[O-])CC1.[Gd+3]
HCID15814656

未命名化合物

PROCEDURE

实验过程

The solution of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid sodium salt is directly reacted, as described in EP 448191, with 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane to give the alkylated product, which can, easily be complexed with gadolinium to give the final Gadobutrol.

WORKUP

后处理

  1. customto give the alkylated product, which can,