Hydrochloric Acid → HCID 19359029, compound

Participants

Reaction Conditions

Reaction Steps

To 275 mg of the product of Example 13 was added 4 ml of freshly made 1M potassium t-butoxide in DMSO. The reaction was heated in a 40° C. oil bath and monitored by Mass Spectra for the appearance of product ion. The mixture was poured into 200 ml of cold 1N hydrochloric acid and stirred in the cold for 1 hour. The resulting precipitate was collected, washed with 1N hydrochloric acid and a little water, and dried in vacuo to give the desired product, 3-chloro-7-[2-(2-chloro-3,4-di-methoxyphenyl)-acryloylamino]dibenzothiophene-2,8-dicarboxylic acid.

Provenance & Evidence