反应详情

A reaction of 109 mmol of 2,5-dibromopyrimidine, 109 mmol of 2-butoxypyridine-5-boronic acid, 218 mmol of sodium carbonate and 1.1 mmol of tetrakis(triphenylphosphine)palladium(0) in 200 ml of toluene, 100 ml of ethanol and 100 ml of water is carried out analogously to the procedure indicated for precursor 3. Corresponding purification gives 12.4 g (37%) of a colorless solid, m.p. 134-138° C.

1. custompurification