HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 5-Bromo2-(6-dodecyloxypyridin-3-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2,5-Dibromopyrimidine | HCID 10955588 | — |
| Reactant | 2-Dodecyloxypyridine-5-boronic acid | HCID 22412821 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Bromo2-(6-dodecyloxypyridin-3-yl)pyrimidine | HCID 17869404 | 35% |
Reaction Steps
A reaction of 35 mmol of 2,5-dibromopyrimidine, 27 mmol of 2-dodecyloxypyridine-5-boronic acid, 64 mmol of sodium carbonate and 0.3 mmol of tetrakis(triphenylphosphine)palladium(0) in 210 ml of toluene, 135 ml of ethanol and 70 ml of water is carried out analogously to the procedure indicated for precursor 3. Corresponding purification gives 3.9 g (35%) of a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06022492 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-56f0ed06153c45a2a23023a3db7214b7 |
| Source note | uspto-grants-2000_02 |