HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-[4-(Benzyloxy)-2,3-difluorophenyl]-5-bromopyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2,5-Dibromopyrimidine | HCID 10955588 | — |
| Reactant | 4-Benzyloxy-2,3-difluorobenzeneboronic acid | HCID 15218753 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-[4-(Benzyloxy)-2,3-difluorophenyl]-5-bromopyrimidine | HCID 17869402 | 26.5% |
Reaction Steps
A reaction of 14 mmol of 2,5-dibromopyrimidine, 17 mmol of 4-benzyloxy-2,3-difluorophenylboronic acid, 34 mmol of sodium carbonate and 0.14 mmol of tetrakis(triphenylphosphine)palladium(0) in 100 ml of toluene, 50 ml of ethanol and 50 ml of water is carried out analogously to the procedure indicated for precursor 3. Purification by recrystallization from 2-propanol gives 1.4 g (26%) of a colorless solid, m.p. 138° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06022492 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-bf5b4f514297404a9eba262211402890 |
| Source note | uspto-grants-2000_02 |