HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyl bromide → 2-(4-Butoxy-2,3-difluorophenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyl bromide | HCID 8002 | — |
| Reactant | 2-(2,3-Difluoro-4-hydroxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine | HCID 135597445 | — |
| Product | 2-(4-Butoxy-2,3-difluorophenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine | HCID 19359111 | 69% |
Reaction Steps
The etherification of 2.4 mmol of 2-(2,3-difluoro-4-hydroxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine using 2.7 mmol of 1-bromobutane is carried out analogously to the procedure indicated for Example 3. Corresponding purification gives 0.76 g (69%) of colorless crystals, X 85 SC 156 SA 180 I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06022492 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-18599046615d4eae8ff8d02d0f46e00f |
| Source note | uspto-grants-2000_02 |