HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Bromide → 2-(4-Ethoxy-2,3-difluorophenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Bromide | HCID 6332 | — |
| Reactant | 2-(2,3-Difluoro-4-hydroxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine | HCID 135597445 | — |
| Product | 2-(4-Ethoxy-2,3-difluorophenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine | HCID 19359101 | 51% |
Reaction Steps
The etherification of 2.8 mmol of 2-(2,3-difluoro-4-hydroxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine using 3.0 mmol of 1-bromoethane is carried out analogously to the procedure indicated for Example 3. Corresponding purification gives 0.62 g (51%) of colorless crystals, X 111 SC 122.5 SA 185 I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06022492 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-2657d927dbc24e89ba7ef4944e7ecfe2 |
| Source note | uspto-grants-2000_02 |