1-Piperidinecarboxamide → HCID 53638589, compound

Participants

Reaction Steps

2[[3-(4-Chlorophenyl)-propyl]-succinic acid 4-tert-butyl ester (WO 95/04033) (5 g, 15.3 mmol) was converted to the corresponding piperidine amide by the method described previously (Example 1, Step G). Yield 4.01 g (67%). 1H-NMR: δ (CDCl3), 7.23 (2H, d, J=8.3 Hz), 7.08 (2H, d, J=8.3 Hz), 3.68-3.42 (4H, m), 3.12 (1H, m), 2.69 (1H, dd, J=8.4, 16.4 Hz), 2.62-2.49 (2H, m), 2.29 (1H, dd, J=5.6, 16.4 Hz), 1.72-1.33 (10H, m) and 1.41 (9H, s).

Provenance & Evidence