Ammonia → HCID 18397290, compound

Participants

Reaction Steps

The S-acetyl derivative E7 (70 mg, 0.24 mmol) was dissolved in water (0.6 ml) and concentrated aqueous ammonia (0.4 ml, sp.gr. 0.88) and stirred at room temperature for 1 hour. The reaction mixture was diluted in ethyl acetate and washed with sufficient dilute hydrochloric acid to acidify the aqueous phase. The two-phase system was treated with saturated brine and the organic layer separated, washed with further brine, dried over sodium sulphate and evaporated to afford the title compound as a colourless oil (60 mg, 100%). νmax (CHCl3) 1744, 1722, 1651, 1410 cm-1. δH (CDCl3) 1.52 (3 H, s), 1.60 (3 H, s), 1.81 (1 H, t, J 8.2 Hz), 2.7-2.9 (4 H, overlapping m), 4.55 (1 H, s), 4.75 (2 H, ABq) ppm. EIMS M+ 249.0496; required for C9H15NO3S2, 249.0493.

Provenance & Evidence