HCID 12932122, compound → HCID 15120703, compound

Participants

Reaction Conditions

Reaction Steps

3-Phenylpropylialonic acid (6.14 g) was converted to 2-methylene-5-phenylpentanoic acid (2.1 g, 40%) by the method described in Example 32a). δH (CDCl3) 1.88 (2 H, m, CH2), 2.37 (2 H, t, J 7.6 Hz, CH2), 2.67 (2 H, t, J 7.6 Hz, CH2), 5.68 and 6.33 (2 H, 2×s, ##STR9## 7.26 (5 H, m, Ph). The solid was dissolved in thioacetic acid (5 ml) and heated at 100° C. for 2 hours. Evaporated to give the title compound (2.9 g, 100%); δH (CDCl3) 1.71 (4 H, m, 2×CH2), 2.33 (3 H, s, COCH3), 2.64 (3 H, m, CH, CH2), 3.08 (2 H, m, CH2), 7.27 (5 H, m, Ph).

Provenance & Evidence