HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 2-(Piperidinomethyl)-1-Naphthol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 1-Naphthol | HCID 7005 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Product | 2-(Piperidinomethyl)-1-Naphthol | HCID 241241 | 45% |
Reaction Steps
Brown (Bull. Natl. Inst. Sci. India, No. 31, 167-178, 1965) discloses the following reaction scheme: Mannich reaction of 1-naphthol with piperidine and formaldehyde afforded 2-(piperidinomethyl)-1-naphthol in a yield of 45%. Reduction of 2-(piperidinomethyl)-1-naphthol in the presence of H2 /Pd/SrCO3 afforded 2-methyl-1-naphthol in a yield of 85%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05420362 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-734d68d293cd4cf08ab175f2026e880e |
| Source note | uspto-grants-1995_05 |