Formaldehyde → HCID 19360508, compound

HRID 376895Notes

Reaction equation

HRID 376895 reaction equation
[CH:1]1[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11](=[O:12])[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH2:13]=O.Cl.[CH2:16]([NH:19][CH3:20])[CH:17]=[CH2:18]>C(O)(=O)C>[CH2:16]([N:19]([CH2:13][CH:10]1[CH2:9][CH2:8][CH2:7][C:6]2[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=2[C:11]1=[O:12])[CH3:20])[CH:17]=[CH2:18]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 70003BenzosuberoneHCID 18326499Allyl-methylamine hydrochloride

Product 1

HCID 19360508HCID 19360508, compoundYield 86.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5.2 g 6,7,8,9-tetrahydro-benzocyclohepten-5-one, 0.96 g paraformaldehyde and 10.0 g allyl-methylamine hydrochloride in 60 ml glacial acetic acid were reacted as in example 1, step 1. After analogous work-up, 6.7 g (84.8% of theoretical) 6-[(allyl-methyl-amino)-methyl]-6,7,8,9-tetrahydro-benzocyclohepten-5-one were obtained as a yellowish oil.

Sources & evidence

ORD record
ord-04d22af8698f4725b374779e6fd1d427
Source dataset
uspto-grants-2000_02
Patent number
US06022895

Reaction notes

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