Guanidine → HCID 19360541, compound

Participants

Reaction Steps

3.5 g of CDI were added to a solution of 3.0 g of 3,4-dichlorobenzylmethylamine in 110 ml of THF and it was stirred at RT overnight. After addition of 4.6 g of guanidine, the reaction mixture was again stirred overnight and concentrated on a rotary evaporator, and the residue was stirred with 120 ml of water. The precipitate which was deposited during this process was filtered off with suction, dried in vacuo and dissolved in 50 ml of ethyl acetate and 7 ml of methanol. After addition of ethereal hydrochloric acid and suction filtration of the precipitated product, 3.8 g of N-(3,4-dichlorobenzyl)-N-methylaminocarbonylguanidinehydrochloride were obtained;

Provenance & Evidence