Hydrochloric Acid → HCID 11951932, compound

2.1 g of 2-chloro-5-trifluoromethylbenzaldehyde, 15 ml of methylamine and 2 g of magnesium sulfate were stirred at room temperature for 2 h, the excess methylamine for the most part evaporating. The reaction mixture was diluted with ether, filtered and concentrated in vacuo. The methylbenzimine thus obtained was dissolved in 15 ml of THF and added dropwise to a suspension of 1.5 g of sodium borohydride in 15 ml of THF. After stirring overnight, the mixture was treated with 30 ml of methanol, stirred for a further 30 min and then rendered acidic with dil. hydrochloric acid. It was extracted with tert-butyl methyl ether, and the aqueous phase was rendered alkaline and extracted twice again with tert-butyl methyl ether. After concentrating this extract, 1.0 g of N-(2-chloro-5-trifluoromethylbenzyl)-N-methylamine was obtained.

1. customthe excess methylamine for the most part evaporating
2. additionThe reaction mixture was diluted with ether
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customThe methylbenzimine thus obtained
6. stirringstirred for a further 30 min
7. extractionIt was extracted with tert-butyl methyl ether
8. extractionextracted twice again with tert-butyl methyl ether
9. concentrationAfter concentrating this extract

ORD record

ord-14f7924a83e74a80bd6f1ef440149a7d

Source dataset

uspto-grants-2000_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06022899