Guanidine → HCID 86755113, compound

Participants

Reaction Steps

1.0 g of N-methyl-N-(3-methylsulfonyl-4-phenoxybenzyl)amine and 0.7 g of CDI dissolved in 25 ml of THF were stirred at RT for 2 h. 1.1 g of guanidine were added, the mixture was stirred overnight and the solvent was distilled off on a rotary evaporator. The residue was taken up in 100 ml of water, adjusted to pH 7.6 with 10 percent hydrochloric acid and extracted twice with ethyl acetate. After concentrating, the guanidine derivative obtained was dissolved again in ethyl acetate, and by adding the equivalent amount of methanesulfonic acid was precipitated as the methanesulfonate. 0.8 g of N-methyl-N-(3-methylsulfonyl-4-phenoxybenzyl)aminocarbonylguanidine methanesulfonate was obtained;

Provenance & Evidence