Acetate → HCID 18320530, compound

Participants

Reaction Conditions

Reaction Steps

5-Nitrophenyl triflate 26 (7 g, 18.7 mmol), palldium (II) acetate (88 mg, 0.39 mmol), 1,1'-bis(diphenylphosphino)ferrocene (430 mg, 0.78 mmol) and hplc grade CH3CN (10 ml) were mixed well in a teflon-linked stainless steel bomb. After adding freshly made, pulverized proton sponge formate (5.1 g, 19.6 mmol), the bomb was sealed and heated at 90° C. for 2 h. The reaction mixture was taken up in EtOAc, passed through a silica gel plug, and then purified on a silica gel column, eluting with 0-30% EtOAc/hexanes to yield 1.5 g (35%) methoxynitrobenzaldehyde acetal 27.

Provenance & Evidence