反应详情

温度

130 °C

69.3 g (0.35 mol) of (4-fluorophenyl)-3,3-dimethyl-2-methoxyoxirane and 200 ml of dry morpholine are mixed and heated to reflux temperature (about 130° C.). After 26 h, the unreacted excess morpholine is distilled off. The residue is taken up in toluene and washed with water and saturated sodium chloride solution successively. The toluene solution is dried with MgSO4 and is concentrated. The residue, 88.1 g, crystallizes from ethanol with a melting point of 63-66° C.

1. temperatureheated
2. distillationthe unreacted excess morpholine is distilled off
3. washwashed with water and saturated sodium chloride solution successively
4. dry with materialThe toluene solution is dried with MgSO4
5. concentrationis concentrated
6. customThe residue, 88.1 g, crystallizes from ethanol with a melting point of 63-66° C.