Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Tert-butyl 3-(methanesulfonyloxy)azetidine-1-carboxylate | HCID 10753243 | — |
| Product | HCID 86752430 | HCID 86752430 | — |
Reaction Steps
Piperazine (149.2 g, 8 mol equiv) was heated to a melt and 1-(t-butoxycarbonyl)-3-methanesulphonyloxyazetidine (see (International Patent Application Publication No. WO93/19059) (54.5 g, 217 mmol) was then added. The mixture was heated at 115° C. for 24 hours, then cooled and the excess piperazine removed in vacuo. The residue was purified by flash chromatography (silica, methanol:dichloromethane, 1:19) to give the title compound (51 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06022971 |
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| Source dataset | uspto-grants-2000_02 |
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| ORD ID | ord-e78f43022a064485b6f9a8235c3cb52d |
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| Source note | uspto-grants-2000_02 |
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