Acetonitrile → Morpholin-4-ylsulfamyl chloride

HRID 377030Notes

Reaction equation

HRID 377030 reaction equation
[S:1]([Cl:5])(Cl)(=[O:3])=[O:2].[NH:6]1[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1.C(#[N:14])C>>[O:9]1[CH2:10][CH2:11][N:6]([NH:14][S:1]([Cl:5])(=[O:3])=[O:2])[CH2:7][CH2:8]1

Participants

4

Reactant 3

HCID 6342Acetonitrile2×HCID 8083MorpholineHCID 24648Sulfuryl chloride

Product 1

HCID 13271200Morpholin-4-ylsulfamyl chloride

Procedure

To a solution of sulphuryl chloride (27.7 ml, 3 mol equiv) in acetonitrile (25 ml) under nitrogen was added a solution of morpholine (10 g, 114 mmol) in acetonitrile (25 ml). The reaction was heated under reflux for 15 hours, then cooled to room temperature and concentrated in vacuo to give the title compound (20.45 g).

Workup

  1. temperatureThe reaction was heated
  2. temperatureunder reflux for 15 hours
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-446896773d0946f1973ab114c56d5165
Source dataset
uspto-grants-2000_02
Patent number
US06022971

Reaction notes

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