反应详情

A mixture of 5-[2-(6-methyl-2-pyridyl)ethoxy]benzonitrile (9.62 g), Raney nickel alloy (10.0 g) and 75% formic acid (150 ml) was heated under reflux for 1 hour. The reaction mixture was filtered and the filtrate was concentrated. The residue was diluted with water, alkalinized with 4N-KOH, and extracted with ethyl ether. The ethyl ether layer was washed with water and dried (MgSO4) and the solvent was distilled off. The residue was recrystallized from ethyl etherhexane to give 4-[2-(6-methyl-2-pyridyl)ethoxy]benzaldehyde.

1. temperaturewas heated
2. temperatureunder reflux for 1 hour
3. filtrationThe reaction mixture was filtered
4. concentrationthe filtrate was concentrated
5. additionThe residue was diluted with water
6. extractionextracted with ethyl ether
7. washThe ethyl ether layer was washed with water
8. dry with materialdried (MgSO4)
9. distillationthe solvent was distilled off
10. customThe residue was recrystallized from ethyl etherhexane