HCID 15884727, compound → HCID 15884735, compound

HRID 377161Notes

Reaction equation

HRID 377161 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:14][CH:13]([O:15][CH3:16])[CH2:12][CH2:11][NH:10]1.CO[CH2:19][CH:20]1CCC(C2C=CC=CC=2OC)[NH:21]1.COCC1CCC(C2C=CC=CC=2OC)N1CCN>>[NH2:21][CH2:20][CH2:19][N:10]1[CH2:11][CH2:12][CH:13]([O:15][CH3:16])[CH2:14][CH:9]1[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[O:2][CH3:1]

Participants

4

Reactant 3

HCID 15884727HCID 15884727, compoundHCID 15884729HCID 15884729, compoundHCID 15884734HCID 15884734, compound

Product 1

HCID 15884735HCID 15884735, compound

Procedure

2-(2-Methoxyphenyl)4-methoxypiperidine was converted to the title compound in two steps by the same procedures as the transformation of 2-methoxymethyl-5-(2-methoxyphenyl)-tetrahydropyrrole to 2-methoxymethyl-5-(2-methoxyphenyl)-1-(2-aminoethyl)-tetrahydropyrrole as described above in Preparations 23 and 24. 1H NMR (CDCl3, 400 MHz) δ:3.80 (3H, s, OMe), 3.31 (3H, s, OMe).

Sources & evidence

ORD record
ord-2d5fdbfbfd4c45c48da25fceb7b3acd7
Source dataset
uspto-grants-2000_02
Patent number
US06025350

Reaction notes

Loading…