HCID 18397496, compound → HCID 15887477, compound

Participants

Reaction Steps

360 mg of (R)-(-)-5-(3-isobutenyloxy-4-methoxyphenyl)-5-methyl-2-oxazolidinone is dissolved in 10 ml of ethyl acetate and mixed with 50 mg of palladium/10% carbon. It is hydrogenated until hydrogen absorption is completed. After filtration on diatomaceous earth and concentration by evaporation in a vacuum, an oily residue is obtained. The crude product is purified by chromatography on a silica gel column, with a hexane-acetone mixture as eluant. 186 mg of (R)-(-)-5-(3-isobutyloxy-4-methoxyphenyl)-5-methyl-2-oxazolidinone, melting point 93.7° C., results. [α]D =-24.7°.

Provenance & Evidence