Diethyl Ether → HCID 19358373, compound

Participants

Reaction Steps

A solution of N-t-butoxycarbonylpiperazine (10 g, 53.8 mmol), chloroacetonitrile (4 mL, 1.05 equiv.) and DIEA (10 mL, 1.1 equiv.) in dichloromethane (300 mL) was refluxed overnight. The reaction mixture was evaporated to give a thick oil, which was tritiated with ether (30 mL) and the organic layer was separated and stored in freezer overnight and filtered. The ether solution was evaporated to give the product as a white solid (12.7 g).

Provenance & Evidence