Ammonia → HCID 19358372, compound

HRID 377214Notes

Reaction equation

HRID 377214 reaction equation
[C:1]([CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]([O:12][CH2:13][CH2:14][CH2:15][CH3:16])=[O:11])[CH2:6][CH2:5]1)#[N:2].N>C(O)C.[Ni]>[NH2:2][CH2:1][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]([O:12][CH2:13][CH2:14][CH2:15][CH3:16])=[O:11])[CH2:6][CH2:5]1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 19358373HCID 19358373, compound

Product 1

HCID 19358372HCID 19358372, compoundYield 98.2%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A solution of 1-cyanomethyl-4-butoxycarbonylpiperazine (12 g) in ethanol (100 mL) saturated with ammonia, was hydrogenated over Raney Ni (5 g) at 1000 psi and 80° C. for 8 hours. The resulting mixture was filtered and evaporated to give 1-(2-aminoethyl)-4-butoxycarbonylpiperazine as a solid (12 g).

Workup

  1. filtrationThe resulting mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-ffd32758609f4c2f84c7be39fc60b789
Source dataset
uspto-grants-2000_02
Patent number
US06025372

Reaction notes

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