2-Chloro-N,N-dimethylethylamine → 1-(2-bromobenzyl)-2-(3-methylphenyl)-6-[2 (N,N-dimethylamino)ethoxy]benzimidazole

HRID 377262Notes

Reaction equation

HRID 377262 reaction equation
[Br:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][N:5]1[C:9]2[CH:10]=[C:11]([OH:14])[CH:12]=[CH:13][C:8]=2[N:7]=[C:6]1[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=1.[CH3:26][N:27]([CH2:29][CH2:30]Cl)[CH3:28]>>[Br:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][N:5]1[C:9]2[CH:10]=[C:11]([O:14][CH2:30][CH2:29][N:27]([CH3:28])[CH3:26])[CH:12]=[CH:13][C:8]=2[N:7]=[C:6]1[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=1

Participants

3

Reactant 2

HCID 79012-Chloro-N,N-dimethylethylamineHCID 193539351-(2-Bromobenzyl)-2-(3-methylphenyl)-6hydroxybenzimidazole

Product 1

HCID 193539461-(2-bromobenzyl)-2-(3-methylphenyl)-6-[2 (N,N-dimethylamino)ethoxy]benzimidazole

Procedure

The title compound was prepared essentially as described in Example 117 except that the compound of Example 126 was reacted with 2-(N,N-dimethylamino)ethyl chloride. mp 71° C., NMR, IR, MS 464, 466.

Sources & evidence

ORD record
ord-a6f7daebb6394daf9410d239dc40d79f
Source dataset
uspto-grants-2000_02
Patent number
US06025379

Reaction notes

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