2-Chloropropyldimethylamine → 1-(2-bromobenzyl)-2-(3-methylphenyl)-6-[1-methyl-2-(N, N-dimethylamino)ethoxy]benzimidazole

HRID 377264Notes

Reaction equation

[Br:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][N:5]1[C:9]2[CH:10]=[C:11]([OH:14])[CH:12]=[CH:13][C:8]=2[N:7]=[C:6]1[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=1.[CH3:26][CH:27](Cl)[CH2:28][N:29]([CH3:31])[CH3:30]>>[Br:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][N:5]1[C:9]2[CH:10]=[C:11]([O:14][CH:27]([CH3:26])[CH2:28][N:29]([CH3:31])[CH3:30])[CH:12]=[CH:13][C:8]=2[N:7]=[C:6]1[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=1

Participants

Reactant 2

HCID 927382-Chloropropyldimethylamine

HCID 193539351-(2-Bromobenzyl)-2-(3-methylphenyl)-6hydroxybenzimidazole

Product 1

HCID 193539701-(2-bromobenzyl)-2-(3-methylphenyl)-6-[1-methyl-2-(N, N-dimethylamino)ethoxy]benzimidazole

Procedure

The title compound was prepared essentially as described above except that the compound of Example 126 was reacted with 1-methyl-2-(N,N-dimethylamino)ethyl chloride.

Sources & evidence

ORD record: ord-61f7344bde594149a8383635e0d02772
Source dataset: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06025379

Reaction notes

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