HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(p-Toluenesulfonyl)-5-tributylstannylisoindoline → Ethyl 8-chloro-1-cyclopropyl-7-[2-(p-toluenesulfonyl)isoindolin-5-yl]-1,4-dihydro-4-oxoquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(p-Toluenesulfonyl)-5-tributylstannylisoindoline | HCID 15870854 | — |
| Reactant | 3-Quinolinecarboxylic acid,7-bromo-8-chloro-1-cyclopropyl-1,4-dihydro-4-oxo-,ethyl ester | HCID 19358344 | — |
| Product | Ethyl 8-chloro-1-cyclopropyl-7-[2-(p-toluenesulfonyl)isoindolin-5-yl]-1,4-dihydro-4-oxoquinoline-3-carboxylate | HCID 19358313 | 79% |
Reaction Steps
In the same manner as in Example 1, 0.45 g of ethyl 7-bromo-8-chloro-1-cyclopropyl-1,4-dihydro-4-oxoquinoline-3-carboxylate was reacted with 1.02 g of 2-(p-toluenesulfonyl)-5-tributylstannylisoindoline to obtain 0.54 g of ethyl 8-chloro-1-cyclopropyl-7-[2-(p-toluenesulfonyl)isoindolin-5-yl]-1,4-dihydro-4-oxoquinoline-3-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06025370 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-0eda879b9abe427ba02e358f891c7637 |
| Source note | uspto-grants-2000_02 |