HCID 19358321, compound → HCID 19358350, compound

HRID 377287Notes

Reaction equation

HRID 377287 reaction equation
Br[C:2]1[C:11]([O:12][CH3:13])=[C:10]2[C:5]([C:6](=[O:22])[C:7]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:8][N:9]2[CH:14]2[CH2:16][CH2:15]2)=[CH:4][CH:3]=1.[F:23][C:24]1[CH:32]=[C:31]2[C:27]([CH2:28][N:29]([S:33]([C:36]3[CH:41]=[CH:40][C:39]([CH3:42])=[CH:38][CH:37]=3)(=[O:35])=[O:34])[CH2:30]2)=[CH:26][C:25]=1[Sn](CCCC)(CCCC)CCCC>>[CH:14]1([N:9]2[C:10]3[C:5](=[CH:4][CH:3]=[C:2]([C:25]4[CH:26]=[C:27]5[C:31](=[CH:32][C:24]=4[F:23])[CH2:30][N:29]([S:33]([C:36]4[CH:41]=[CH:40][C:39]([CH3:42])=[CH:38][CH:37]=4)(=[O:34])=[O:35])[CH2:28]5)[C:11]=3[O:12][CH3:13])[C:6](=[O:22])[C:7]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:8]2)[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 19358321HCID 19358321, compoundHCID 19358323HCID 19358323, compound

Product 1

HCID 19358350HCID 19358350, compoundYield 69%

Procedure

In the same manner as in Example 1, 0.23 g of ethyl 7-bromo-1-cyclopropyl-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylate was reacted with 0.63 g of 6-fluoro-2-(p-toluenesulfonyl)-5-tributylstannyliso-indoline to obtain 0.25 g of ethyl 1-cyclopropyl-7-[6-fluoro-2-(p-toluenesulfonyl)isoindolin-5-yl]-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylate.

Sources & evidence

ORD record
ord-60e61d26b36645678bfdc967af959894
Source dataset
uspto-grants-2000_02
Patent number
US06025370

Reaction notes

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