HCID 11103220, compound → HCID 502078, compound

Participants

Reaction Steps

In 14 ml of acetic acid and 140 mg of 5% palladium-carbon was suspended 140 mg of 7-[2-(benzyl-oxycarbonyl)isoindolin-5-yl]-1-cyclopropyl-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, and the suspension was stirred at room temperature for 2 hours under a hydrogen atomsphere. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. Ethanol and diethyl ether were added to the resulting residue and the crystals were collected by filtration. To the crystals collected were added 0.8 ml of ethanol, 0.8 ml of a 1N aqueous sodium hydroxide solution and 0.8 ml of water to dissolve the crystals, after which carbon dioxide was bubbled into the resulting solution and the crystals were collected by filtration to obtain 74 mg of colorless 1-cyclopropyl-7-(isoindolin-5-yl)-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid.

Provenance & Evidence