Hydrochloric Acid → HCID 19358464, compound

Participants

Reaction Steps

A solution of 2-(4,5-diphenyl-2-oxazolyl)-3'-benzyloxybenzhydrol (650 mg) in ethyl acetate (3 ml), methanol (3 ml), and 10% hydrogen chloride in methanol (0.3 ml) was stirred in the presence of 10% palladium on carbon--water (50/50 wt. % ) (400 mg) and hydrogen at atmospheric pressure at room temperature for 10 hours. The reaction mixture was filtered and the filtrate was evaporated in vacuo. The residue was chromatographed (toluene--ethyl acetate) over silica gel to afford 3-[[2-(4,5-diphenyl-2-oxazolyl)phenyl]methyl]phenol (150 mg) as a colorless powder.

Provenance & Evidence