Sodium Hydroxide → Sodium [3-[[2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl]methyl]phenoxy]acetate

HRID 377330Notes

Reaction equation

HRID 377330 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([C:18]3[CH:19]([CH2:24][C:25]4[CH:26]=[C:27]([CH:35]=[CH:36][CH:37]=4)[O:28][CH2:29][C:30]([O:32]CC)=[O:31])[CH2:20][CH2:21][CH2:22][CH:23]=3)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+:39]>COCCOC.C(O)C>[C:1]1([C:7]2[N:8]=[C:9]([C:18]3[CH:19]([CH2:24][C:25]4[CH:26]=[C:27]([CH:35]=[CH:36][CH:37]=4)[O:28][CH2:29][C:30]([O-:32])=[O:31])[CH2:20][CH2:21][CH2:22][CH:23]=3)[O:10][C:11]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1.[Na+:39]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 54289111Ethyl [3-[[2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl]methyl]phenoxy]acetate

Product 1

HCID 23694021Sodium [3-[[2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl]methyl]phenoxy]acetate

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 80711,2-DimethoxyethaneSolvent

Procedure

A solution of ethyl [3-[[2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl]methyl]phenoxy]acetate (355 mg) and 1N sodium hydroxide aqueous solution (0.71 ml) in 1,2-dimethoxyethane (6 ml) and ethanol (6 ml) was stirred at room temperature for 2 hours and evaporated in vacuo. The solid residue was washed with diethyl ether to afford sodium [3-[[2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl]methyl]phenoxy]acetate (308 mg) as a pale yellow powder.

Workup

  1. customevaporated in vacuo
  2. washThe solid residue was washed with diethyl ether

Sources & evidence

ORD record
ord-16149f7f6e1f44b79fe9de57c3d317b0
Source dataset
uspto-grants-2000_02
Patent number
US06025375

Reaction notes

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