反应详情

To p-fluoro-α-methylcinnamic acid (177.9 g, 0.987 mole) in 3.6 liters ethanol is added 11.0 g of 5% Pd/C and the mixture is reduced at room temperature under a hydrogen pressure of 40 p.s.i.; uptake is 31-32 lbs. (97% of theoretical). After the catalyst is filtered, the filtrate is concentrated in vacuo to give the product p-fluoro-α-methylhydrocinnamic acid that is used without weighing in next step.

1. customis reduced at room temperature under a hydrogen
2. filtrationAfter the catalyst is filtered
3. concentrationthe filtrate is concentrated in vacuo