4-Amino-1,2,2,6,6-pentamethylpiperidine → HCID 18397576, compound

Participants

Role	Name	HCID	Charge
Reactant	4-Amino-1,2,2,6,6-pentamethylpiperidine	HCID 693792	—
Reactant	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Reactant	HCID 10955790	HCID 10955790	—
Reactant	1-Hydroxy-7-azabenzotriazol hydrate	HCID 21917466	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 18397576	HCID 18397576	42.8%

Reaction Steps

A solution of (2Z,4E)-5-(benzofuran-2-yl)-2-methoxy-2,4-pentadienoic acid (122 mg, 0.5 mmol), 4-amino-1,2,2,6,6-pentamethylpiperidine (85 mg, 0.5 mmol), 1-hydroxy-7-azabenzotriazole hydrate (65 mg, 0.5 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (95 mg, 0.5 mmol) in DMF (2 ml) was stirred at RT overnight. After the same work-up described in example 3 the residue was triturated with isopropyl ether to produce a solid that was recovered and dried to give pure title compound (85 mg, 0.214 mmol, yield 42.8%) as yellow crystals, m.p.=152°.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06025390
Source dataset	uspto-grants-2000_02
ORD ID	ord-68d9ef7d8f504893b8a92ef1aa2a0dba
Source note	uspto-grants-2000_02