HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Triphenylphosphoranylidene)acetaldehyde → (E)-3-(5-Chlorobenzofuran-2-yl)-prop-2-enal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Triphenylphosphoranylidene)acetaldehyde | HCID 75051 | — |
| Reactant | 5-Chloro-1-benzofuran-2-carbaldehyde | HCID 13400170 | — |
| Reactant | Ethylacetate heptane | HCID 21899848 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-3-(5-Chlorobenzofuran-2-yl)-prop-2-enal | HCID 19358687 | 68.9% |
Reaction Steps
A solution of 5-chlorobenzofuran-2-carboxaldehyde (813 mg, 4.50 mmol) and formylmethylene triphenylphosphorane (1.37 g, 4.50 mmol) in CH2Cl2 (40 ml) was treated as sen in preparation 1. After a chromatography on silicagel (n-heptane/EtOAc 4/1) pure title compound (640 mg, 3.10 mmol, yield 68.8%) as yellow crystals was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06025390 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-1105720e67994fec882afba7b638ffd7 |
| Source note | uspto-grants-2000_02 |