HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethyl-1,3-propanediamine → HCID 86755126, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethyl-1,3-propanediamine | HCID 7993 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 19358675 | HCID 19358675 | — |
| Reactant | 1-Hydroxy-7-azabenzotriazol hydrate | HCID 21917466 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86755126 | HCID 86755126 | 48% |
Reaction Steps
A solution of (2Z,4E)-5-(5-chlorobenzofuran-2-yl)-2-methoxy-2,4-pentadienoic acid (88 mg, 0.32 mmol), 3-dimethylamino propylamine (46 mg, 0.35 mmol), 1-hydroxy-7-azabenzotriazole hydrate (44 mg, 0.32 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (62 mg, 0.5 mmol) in DMF (2 ml) was stirred at RT for 6 hours. After the same work up as seen in example 3 pure title compound was obtained (60 mg, 0.153 mmol, yield 48.0%) as yellow crystals, mp.=150° dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06025390 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-b6609cda7ef641f7b067d160056b93f2 |
| Source note | uspto-grants-2000_02 |