HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-1,2,2,6,6-pentamethylpiperidine → HCID 18397577, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-1,2,2,6,6-pentamethylpiperidine | HCID 693792 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 19358669 | HCID 19358669 | — |
| Reactant | 1-Hydroxy-7-azabenzotriazol hydrate | HCID 21917466 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18397577 | HCID 18397577 | 26.6% |
Reaction Steps
A solution of (2Z,4E)-5-(benzothiophen-2-yl)-2-methoxy-2,4-pentadienoic acid (53 mg, 0.20 mmol), 4-amino-1,2,2,6,6-pentamethylpiperidine (34 mg, 0.20 mmol), 1-hydroxy-7-azabenzotriazole hydrate (27 mg, 0.20 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (38 mg, 0.20 mmol) in DMF (1 ml) was stirred at RT for 6 hours. After the same work up as seen in example 3 pure title compound was obtained (22 mg, 0.054 mmol, yield 26.6%) as white crystals, m.p.=240°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06025390 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-9db2d1dfca59411197f64a343fdb4761 |
| Source note | uspto-grants-2000_02 |