4-Bromothiophenol → 5-Bromo-1-benzothiophene

Participants

Reaction Steps

5-Bromobenzo[b]thiophene was prepared in quantitative yield for two steps from 4-bromobenzenethiol and bromoacetaldehyde dimethyl acetal as described in the preparation of 4- and 6-methoxybenzo[b]thiophene (see Example 92, Part A): mp 40-43.5° C; FDMS 212.1 (M-1); Anal. Calcd for C8H5BrS.0.10C7H8OS: C, 46.01; H, 2.57; S, 15.53. Found: C, 46.19; H, 2.49; S, 15.79.

Provenance & Evidence