Imidazole → HCID 88254428, compound

Participants

Reaction Steps

13.2 g (49.9 mmol) of 2-chloro-1-diphenylphosphorylethane are, with addition of 7 ml (50 mmol) of triethylamine, reacted in a mixture of 50 ml of toluene and 30 ml of ethanol with 3.4 g (50 mmol) of imidazole. The mixture is refluxed for 5 hours. The resulting 1-imidazole-2-(diphenylphosphoryl)ethane is quaternized at room temperature with 3.13 ml (50 mmol) of methyl iodide. 1-methyl-3-(2-diphenylphosphorylethyl)imidazolium iodide is precipitated by addition of 100 ml of diethyl ether and dried under reduced pressure. This results in 15.7 g (65%) of (11a) as the monoethanol adduct.

Provenance & Evidence