{[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-tert-butoxycarbonylmethyl-amino}-aceticacid tert-butyl ester → {[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-carboxymethyl-amino}-acetic acid

HRID 37745Notes

Reaction equation

HRID 37745 reaction equation
C([O:5][C:6](=[O:34])[CH2:7][N:8]([S:17]([C:20]1[CH:25]=[CH:24][C:23]([O:26][C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH2:9][C:10]([O:12]C(C)(C)C)=[O:11])(C)(C)C>C(O)=O>[F:33][C:30]1[CH:31]=[CH:32][C:27]([O:26][C:23]2[CH:22]=[CH:21][C:20]([S:17]([N:8]([CH2:7][C:6]([OH:34])=[O:5])[CH2:9][C:10]([OH:12])=[O:11])(=[O:19])=[O:18])=[CH:25][CH:24]=2)=[CH:28][CH:29]=1

Participants

3

Reactant 1

HCID 67312951{[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-tert-butoxycarbonylmethyl-amino}-aceticacid tert-butyl ester

Product 1

HCID 66916729{[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-carboxymethyl-amino}-acetic acid

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

{[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-tert-butoxycarbonyl methyl-amino}-acetic acid tert-butyl ester (4b) (1.00 g, 2.03 mmol) was dissolved in formic acid (10 mL) and stirred overnight at room temperature.

Sources & evidence

ORD record
ord-abdd2696e4ea4b9884b1a01c9ed2ecdb
Source dataset
uspto-grants-2013_09
Patent number
US08524194B2

Reaction notes

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