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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 377454Generated: October 25, 2026

p-(Trifluoromethoxy)benzaldehyde → Ethyl 1,2,3,4-tetrahydro-1-(4-trifluoromethoxyphenyl)-9h-pyrido(3,4-b)indole-3-carboxylate

https://huagongshe.com/reaction/377454

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-(Trifluoromethoxy)benzaldehydeHCID 69573—
ReactantL-Tryptophan, ethyl esterHCID 81996—
ProductEthyl 1,2,3,4-tetrahydro-1-(4-trifluoromethoxyphenyl)-9h-pyrido(3,4-b)indole-3-carboxylateHCID 22619830—

Reaction Steps

The same method but starting from racemic tryptophan ethyl ester and 4-trifluoromethoxybenzaldehyde gave cis and trans isomers of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06025494
Source datasetuspto-grants-2000_02
ORD IDord-42975b34b0d948b59f8e8ce9116df3aa
Source noteuspto-grants-2000_02