Acetyl chloride → HCID 20637914, compound

Participants

Reaction Steps

To a solution of Example 98 (0.2 g) in THF (15 mL) was added triethylamine (76 μL) and acetyl chloride (39 μL) and the resulting solution was stirred at room temperature for 2 hours. After evaporation of THF, the resulting residue was taken up in CH2Cl2 (100 mL), washed with water (2×50 mL) and dried over Na2SO4. After evaporation of CH2Cl2, the resulting solid was recrystallised from MeOH/H2O to give the title compound as a cream powder (120 mg) m.p.: 246° C.

Provenance & Evidence